Her lab currently focuses on immune pathogenesis and novel treatment strategies for pediatric-onset diseases that affect the function of the body’s internal organs, such as inflammatory bowel diseases, biliary atresia, asthma, systemic lupus erythematosus and IgA nephrology. They also investigate immune-genetic mechanisms underlying autoinflammatory diseases, primary immune deficiency and metabolic syndromes. They employ cutting-edge techniques including single cell RNA sequencing, whole genome-wide association study, whole exosome sequencing, comparative immune profiling, animal experiments and clinical trials to identify how risk and disease causal genes regulate immune and non-immune cell development and function.